Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors
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چکیده
منابع مشابه
Goblet Cells Contribute to Ocular Surface Immune Tolerance—Implications for Dry Eye Disease
Conjunctival goblet cell (GC) loss in dry eye is associated with ocular surface inflammation. This study investigated if conjunctival GCs contribute to ocular surface immune tolerance. Antigens applied to the ocular surface, imaged by confocal microscopy, passed into the conjunctival stroma through goblet cell associated passages (GAPs) in wild type C57BL/6 (WT), while ovalbumin (OVA) was retai...
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Keratoplasty is the oldest and one of the most successful forms of solid tissue transplantation. In the United States, over 33,000 corneal transplants are performed each year. Unlike other forms of tissue transplantation, keratoplasties are routinely performed without the aid of tissue typing or systemic immunosuppressive drugs. In spite of this, 90% of the first-time corneal transplants will s...
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متن کاملImmune checkpoints
1 This recognition was largely driven by the success of ipilim-umab, the monoclonal antibody that targets cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor expressed on activated CD8 + T cells. CTLA-4 attenuates the immune response by countering the activity of CD28, a co-stimulatory receptor. 2 By targeting CTLA-4, ipilimumab effectively takes the " brakes " off T ce...
متن کاملImmune Privilege
T he concept of immune privilege refers to the observation that tissue grafts placed in certain anatomical sites, including the brain and eye, can survive for extended periods of time (1). Immune privilege is thought to reflect an evolutionary adaptation to protect vital structures from damage by inflammatory responses directed against pathogens. It was originally believed that antigens in immu...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21113962